In 2019, the EPMA famous its 10th anniversary at the 5th World Congress in Pilsen, Czech Republic. 2009; currently, the EPMA is usually represented in 54 countries worldwide who actively promote 3PM concepts in bio/medical sciences and practical medicine strongly benefiting patients and healthcare systems. The first issue of?the EPMA Journal, 10.1186/1878-5085-3-14. 10.1186/s13167-016-0072-4. top-ranks the EPMA J. in all three categories, namely in Cancer, Metabolic Disorders, Cardiovascular Disease, Neurological, Neurodegenerative and Neuropsychiatric Disorders, Inflammatory Disorders, Dentistry, Biobanking and Screening Programmes, Multi-omics, Microbiome, Immune-, Pre- and Probiotics, and Innovative Technologies, among others. Further, there were several new topics presented at the congress: among others these were Implementation of 3PM Concepts in Plastic Surgery, Application of Artificial Intelligence in Medicine C 3PM strategies and Medical Use of Cannabis. The latter topic was discussed in the EU Parliament in 2019, and the EPMA position has been elucidated by the EPMA Representatives; for more information see the below link: http://www.epmanet.eu/latest/events/2019/epma-position-on-medical-use-of-cannabis-presented-at-the-eu-parliament. Oral and poster presentations provided valuable information regarding pilot projects towards personalised healthcare (e.g. awarded by ICPerMed), individualised patient profiles, multi-level biomarker panels, patient stratification, creation and application of innovative IT-tools, ethical issues, doctor-patient collaboration, optimal structure and organisation of the modern hospital ambitioned to practically implement the paradigm change from reactive to predictive, preventive and personalised medicine. World First 3P Medical Unit In March 2020, the historically first worldwide unit dedicated to Predictive, Preventive and Personalised (3P) Medicine led by Secretary-General of the EPMA, Prof. Dr. Olga IMD 0354 Golubnitschaja, was created in Germany at the Department of Radiation Oncology,?University Hospital,?Rheinische Friedrich-Wilhelms-Universit?t Bonn. 3PM vision and strategies PPPM for Twenty-first Century Biosensing: Painless, Personalised, Point-of-Care Monitoring with Wearable and Implantable Devices Andrews RA* *Corresponding author:?Nanotechnology & Smart Systems, 121 NASA Ames Research Center, 122 Moffett Field, CA, USA; e.mail: firstname.lastname@example.org Keywords: Rabbit Polyclonal to MT-ND5 Artificial intelligence, Biosensors, Blood pressure monitoring, Brain-computer/Brain-machine interface, Continuous monitoring, Diabetes, Electrocardiogram, Electroencephalogram, Epilepsy, Fall detection, Gait disorders, Glucose monitoring, Implantable sensors, Ingestible sensors, Internet of things, Iontophoresis, Interstitial fluid, Nanosensors, Neurotechnology, Pressure monitoring, Saliva monitoring, Seizure detection, Smart contact lenses, Smart mouthguards, Smart patches, Smart skin, Smart IMD 0354 watches, Smartphone apps, Skin patches, Sweat monitoring, Tear monitoring, Heat monitoring, Tissue-device interface, Wearable sensors, Wireless monitoring Introduction Many people do not realize they have adopted wearable devices for medical monitoringsmartwatches already. Typical tales of smartwatches offering life-saving diagnostic details include the pursuing: (1) A smartwatch alarming forever regarding unusual heartrate alerted the wearer to get medical assistance for what became atrial fibrillation ; (2) IMD 0354 A hikerlost as nightfall approachedstumbled and dropped on difficult ground. Unbeknownst towards the hiker, the fall brought about his smartwatch to immediately call the crisis contact number (911 in america), staying away from what might have been a tragic final result thereby. Smartphones, with accelerometer and Gps navigation capabilities, have got apps for those who have epilepsy who may necessitate emergency medical attention . Medical monitoring is not therefore pain-free, consistent, and unobtrusive. IMD 0354 Atrial fibrillation needed attaching electrodes to your skin using a conductive gel, subsequently linked to a portable devicepossibly, but obtrusive certainly. Monitoring of blood sugar by diabetics needed repeated finger-stickspainful, intermittent, and obtrusive. Stages of Biofluid Monitoring Diagnostic approaches for biofluids, e.g., bloodstream, urine, saliva, and cerebrospinal liquid (CSF), possess evolved within the last several years (Fig.?1) . The initial phaseextending in the twentieth century towards the presententails finding a test from the individual (an invasive process of bloodstream and CSF) and sending it to a lab for analysis. Email address details are not available all night to times for samples extracted from outpatients, and moments to hours for inpatients. Fig.?1 The four technological waves of biochemical monitoring. (reference , with permission) The second phase began about two decades ago with point-of-care (POC) monitoring, where the laboratory.