Association between characteristics of the population and Diastolic Left Ventricular Dysfunction (DLVD) in men and women, results from multinomial logistic regression adjusted for age. challenge, with high health care expenditures, high prevalence, and poor clinical outcomes. The objective was to analyse the sex-specific association of socio-demographics, life-style factors and health characteristics with the prevalence of HF and diastolic left ventricular dysfunction (DLVD) in a cross-sectional population-based study. Methods A random sample of 2001 65C84?year-olds underwent physical examination, laboratory measurements, including N-terminal pro-B-type natriuretic peptide (NT-proBNP), electrocardiography, and echocardiography. We selected the subjects with no missing values in covariates and echocardiographic parameters and performed a complete case analysis. Sex-specific multivariable logistic regression models were used to identify the factors associated with the prevalence of the diseases, multinomial logistic regression was used to investigate the factors connected to asymptomatic and symptomatic LVD, and spline curves to display the relationship between the conditions and both age and NT-proBNP. Results In 857 males included, there were 66 instances of HF and 408 instances of DLVD (77% not reporting symptoms). In 819 ladies, there were 51 instances of HF and 382 of DLVD (79% not reporting symptoms). In males, the factors associated with prevalence of HF were age, ischemic heart disease (IHD), and suffering from three or more comorbid conditions. In ladies, the factors associated with HF were age, life styles (smoking and alcohol), BMI, hypertension, and atrial fibrillation. Age and diabetes were connected to asymptomatic DLVD in both genders. NT-proBNP levels were more strongly associated with HF in males than in ladies. Conclusions There were sex variations in the factors associated with HF. The results suggest that prevention policies should consider the sex-specific impact on cardiac function of modifiable cardiovascular risk factors. Supplementary Information The online version consists of supplementary material available at 10.1186/s12889-021-10442-3. strong class=”kwd-title” Keywords: Heart failure, Diastolic remaining ventricular dysfunction, Sex variations, Risk factors, Elderly, NT-proBNP Background Heart failure (HF) is definitely a clinical syndrome characterised by symptoms and indicators of increased cells/organ fluid retention and decreased cells/organ perfusion [1C4]. Together with the ageing of the population, the prevalence of heart failure continues to increase worldwide, and it has high rates of morbidity and mortality, leading to enormous human, interpersonal, and economic costs . Therefore, the growing epidemic of heart failure is one of the major health problems in the developed countries . Since people with heart failure develop symptoms gradually, given Araloside V the progressive nature of the disease characterised by a long preclinical phase, early interventions to prevent the disease are hypothetically possible [1C4]. Early acknowledgement of medical HF is critical to prevent recurrences of HF and hospitalisations due to decompensation . Sex variations in the prevalence, demonstration, management, and results of different cardiovascular diseases have been found, and gender-specific medicine has received growing attention in recent years [5C9]. Sex variations in the demonstration of HF may play an important part in the progression of the disease, in the development of relevant prognostic comorbidities, and actually in the response to therapies [10, 11]. Although sex is definitely recognised like a modifier of health, disease, and medicine, the diagnostic and restorative methods are not differential by sex [12, 13]. Araloside V The present study aimed at evaluating the self-employed association of traditional cardiovascular risk factors with HF and diastolic remaining ventricular dysfunction (DLVD) in men and women aged 65C84?years from your PREDICTOR study database. In particular, we investigated whether you will find sex variations in the association between age and the prevalence of the diseases, and whether you will find sex variations in the association of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the prevalence of HF and DLVD. Methods The PREDICTOR study PREDICTOR is definitely a cross-sectional population-based study. The design, study population, and methods have been explained elsewhere [14, 15]. Briefly, a random sample of 5940 occupants, aged 65C84, from four towns in the Lazio region (5.5 million inhabitants) was identified using the TNR Regional Health Registry of 1 1 June 2007. The final Araloside V sample size was identified a priori to estimate a prevalence of 3% for HF and of 30% for LVD having a significance level of P 0.05 assuming a 30% participation rate. In total, 5940 people were invited to participate by mail and were informed of the aims and the Araloside V methodology of the survey. The reasons for refusal to participate included old age, major disability, severe comorbidities, and troubles in reaching the cardiology center. In total, 2001 subjects agreed to participate and underwent physical.